When is the maximum vascularity of granulation tissue typically reached?

The maximum vascularity of granulation tissue is typically reached around day 5 of the healing process. During this period, the healing tissue actively proliferates, and there is an increase in the formation of new blood vessels, a phenomenon known as angiogenesis. This is crucial because enhanced blood supply brings in necessary nutrients and oxygen, supporting the metabolic needs of the healing tissue.

Around this timeframe, fibroblasts are also actively producing collagen and other extracellular matrix components, which are vital for the stability and strength of the healing tissue. The peak of vascularity at day 5 highlights a key phase in the healing process, where the body is effectively laying down the framework for new tissue.

The subsequent days after this peak will still show granulation tissue maturation and remodeling, but the maximum level of vascularization is a critical indicator of healing progression that is specifically identified around the fifth day post-injury.