What occurs during the necrosis stage of graft maturation?

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During the necrosis stage of graft maturation, the primary event is the presence of initial degenerative changes in the graft, which includes the death or loss of intrinsic graft cells due to a lack of adequate blood supply or other factors. As this process progresses, replacement cells begin to appear while existing graft cells diminish. This represents a critical transitional phase whereby the body prepares to replace the necrotic tissue with new cells, setting the stage for subsequent healing and integration of the graft into the surrounding tissue.

The emergence of replacement cells signifies that the body is working to restore functionality and structure to the graft area, reflecting the body's dynamic response to tissue damage. Understanding this stage is essential for orthopaedic rehabilitation, as it informs therapeutic approaches to support graft integration and avoid complications.

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