What occurs during the maturation phase of soft tissue repair?

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During the maturation phase of soft tissue repair, a number of critical processes occur that are essential for the proper healing and strength of the tissue. One of the most significant events is the increase in collagen synthesis. This increase leads to the formation of a more organized and stronger scar tissue. As the healing progresses, the primary scar that initially forms becomes more refined and structurally more similar to the surrounding tissue.

Additionally, during this phase, leukocytes that were present in the earlier stages of healing typically exit the area as the inflammatory response subsides. This shift allows other healing cells, such as fibroblasts, to contribute more effectively to the repair process, accumulating collagen and promoting tissue strength. The maturation phase can last for several months to years, highlighting the importance of collagen remodeling and the transition from a provisional extracellular matrix to a more stable one. Overall, the maturation phase is characterized by increased collagen synthesis, reduced cellularity, and the formation of a more resilient scar.

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