How does the extracellular matrix change during the maturation phase?

During the maturation phase of healing, the extracellular matrix (ECM) undergoes significant remodeling to achieve optimal strength and size necessary for tissue functionality. This phase is characterized by the reorganization of collagen fibers, where the initially laid-down collagen, which is often disorganized and weak, is replaced and aligned according to the lines of stress and tension experienced by the tissue.

As the healing process progresses, fibroblasts continue to synthesize collagen and other components of the ECM. The type of collagen may also shift from type III (which is prominent during the inflammatory and early proliferative phases) to type I, which is stronger and provides greater tensile strength. This remodeling leads to an increase in the overall strength of the repaired tissue as it matures and prepares for normal functional loads.

Thus, the correct response highlights the critical phase where the ECM is actively involved in regaining its integrity and function, ultimately allowing for proper recovery and function of the affected area.